A stroke happens when blood supply to the brain is interrupted or reduced, either by a blockage (ischemic stroke) or a blood vessel rupture (hemorrhagic stroke). This leads to rapid cell death due to oxygen and nutrient deprivation, causing various symptoms and complications depending on the affected brain area. Quick treatment is vital to minimize brain damage and enhance recovery prospects.

Therapeutic hypothermia, or targeted temperature management, aims to improve outcomes in patients with acute ischemic stroke. It involves lowering the body's core temperature to a specific target range for a defined period. Hypothermia therapy for stroke aims to reduce brain inflammation, metabolic rate, and secondary brain injury. By protecting brain tissue, minimizing harmful chemical release, and improving neurological outcomes, hypothermia offers potential benefits in stroke treatment.

Oral mucositis is inflammation and ulceration of the mouth and throat lining, often caused by cancer treatments like chemotherapy and radiation therapy. It leads to discomfort, pain, and difficulty in eating, swallowing, and speaking. The severity varies from mild redness to severe ulcers and bleeding, with an increased risk of infections. It typically occurs shortly after starting cancer treatment and may persist throughout or after treatment. Managing oral mucositis is crucial for improving quality of life and preventing complications.

Cryotherapy for oral mucositis involves applying cold temperatures to reduce its severity and duration. It constricts blood vessels, reducing blood flow and minimizing damage from chemotherapy or radiation. Cryotherapy aims to decrease inflammation, alleviate pain, and promote healing. Patients use cold treatment before, during, and after sessions to numb the mouth, enhance comfort, and facilitate eating, drinking, and oral hygiene.